Pharmacognosy Magazine
Search Article 
  
Advanced search 
   Journal of Cardiovascular Disease Research
 
 
 
Home  |  About us  |  Editorial board  |  Search  |  Ahead of print  |  Current Issue  |  Archives  |  Instructions  |  Subscribe  |  Contact us |    Login  Users online: 8
Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
 
 
ORIGINAL ARTICLE
Year : 2012  |  Volume : 3  |  Issue : 2  |  Page : 99-103

Variability in cardiovascular functions and baroflex sensitivity following inhalation of petroleum hydrocarbons


1 Department of Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria
2 Department of Physiology, College of Medicine, University of Lagos, Lagos, Nigeria

Correspondence Address:
R E Akhigbe
P.M. B. 4000, Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State
Nigeria
Login to access the Email id


DOI: 10.4103/0975-3583.95361

Get Permissions

Objective: Although petroleum products are useful chemical compounds which form an integral part of our modern technology, they have been reported to cause deleterious effect on health following their inhalation. Petroleum hydrocarbons-dependent health hazards and their mechanisms have been associated with the routes of administration. This study, therefore, aimed at the isolation and chemical characterization of various petroleum products, and also investigating in rat model of Sprague dawley strain, the variability in cardiovascular functions and possible mechanism following inhalation of petroleum products. Materials and Methods: Control rats were not exposed to any form of petroleum products, while the petrol-exposed, diesel-exposed, and kerosene-exposed were exposed to petrol, diesel, and kerosene respectively. Results: When compared with the controls, all exposed groups showed a significant (P<0.05) increase in the systolic blood pressure, diastolic blood pressure, mean arterial pressure (MAP), and heart rate (HR). In comparison with the control, exposure to petroleum products also led to significant (P<0.05) increase in baroreflex sensitivity in the diesel- and kerosene-exposed rats. Baroreflex sensitivity was comparable in the control and petrol-exposed rats (P>0.05). Body weight gain was significantly (P<0.05) reduced in petroleum products exposed rats. Conclusion: These results suggest that the variability of cardiovascular functions associated with inhalation of petroleum products is in attendant to baroreflex sensitivity and resetting of arterial pressure.


[FULL TEXT] [PDF]*
Print this article     Email this article
Search Again
 Back
 Table of Contents
 
 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
  • Azeez O M
  • Akhigbe R E
  • Anigbogu C N
  • Ige S F
  • Saka W A
 Related articles
 Citation Manager
 Article Access Statistics
 Reader Comments
 Email Alert
 Add to My List
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed570    
    Printed68    
    Emailed1    
    PDF Downloaded74    
    Comments [Add]    

Recommend this journal