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Inflammation and diabetic retinal microvascular complications
Wenbo Zhang1, Hua Liu2, Mohamed Al-Shabrawey3, Robert W Caldwell4, Ruth B Caldwell5
1 Vascular Biology Center, Vision Discovery Institute and Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, Georgia, USA
2 Vascular Biology Center and Vision Discovery Institute, Georgia Health Sciences University, Augusta, Georgia, USA
3 Vision Discovery Institute and Department of Oral Biology and Anatomy, Georgia Health Sciences University, Augusta, Georgia, USA
4 Department of Pharmacology and Toxicology, Georgia Health Sciences University, Augusta, Georgia, USA
5 Vascular Biology Center, Vision Discovery Institute, Department of Cellular Biology, Anatomy and Ophthalmology, Georgia Health Sciences University, Augusta; VA Medical Center, Augusta, Georgia, USA
Correspondence Address:
Wenbo Zhang
Vascular Biology Center, Georgia Health Sciences University, Augusta, Georgia 30912-2500
USA
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DOI: 10.4103/0975-3583.83035 PMID: 21814413
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Diabetic retinopathy (DR) is one of the most common complications of diabetes and is a leading cause of blindness in people of the working age in Western countries. A major pathology of DR is microvascular complications such as non-perfused vessels, microaneurysms, dot/blot hemorrhages, cotton-wool spots, venous beading, vascular loops, vascular leakage and neovascularization. Multiple mechanisms are involved in these alternations. This review will focus on the role of inflammation in diabetic retinal microvascular complications and discuss the potential therapies by targeting inflammation. |
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