| INVITED REVIEW |
|
| Year : 2010 | Volume
: 1
| Issue : 4 | Page : 165-170 |
|
|
The role of RhoA/Rho kinase pathway in endothelial dysfunction
Lin Yao1, Maritza J Romero1, Haroldo A Toque1, Guang Yang2, Ruth B Caldwell2, R William Caldwell1
1 Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA, USA
2 Department of Vascular Biology Center, Medical College of Georgia, Augusta, GA, USA
Correspondence Address:
R William Caldwell
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA, 30912
USA
  | 2 |
DOI: 10.4103/0975-3583.74258 PMID: 21264179
|
|
|
Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction. |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
Similar in PUBMED