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Year : 2010  |  Volume : 1  |  Issue : 4  |  Page : 165-170

The role of RhoA/Rho kinase pathway in endothelial dysfunction

1 Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA, USA
2 Department of Vascular Biology Center, Medical College of Georgia, Augusta, GA, USA

Correspondence Address:
R William Caldwell
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA, 30912
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PMC citations2

DOI: 10.4103/0975-3583.74258

PMID: 21264179

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Endothelial dysfunction is a key event in the development of vascular disease, and it precedes clinically obvious vascular pathology. Abnormal activation of the RhoA/Rho kinase (ROCK) pathway has been found to elevate vascular tone through unbalancing the production of vasodilating and vasoconstricting substances. Inhibition of the RhoA/ROCK pathway can prevent endothelial dysfunction in a variety of pathological conditions. This review, based on recent molecular, cellular, and animal studies, focuses on the current understanding of the ROCK pathway and its roles in endothelial dysfunction.

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